Protein nutrition for cells and organisms: Can we use it to treat diseases?
The review highlights the demand for better inhibitors of amino acid transport processes and outlines promising new strategies and targets to develop amino acid transporters as drug targets. Cancer cells, for instance, need essential amino acids to proliferate and metastasize. Amino acid transporters are essential for capturing of nutrients from blood vessels, which can be blocked by specific inhibitors.
This is an area of active research and a promising strategy to treat cancer. In the brain, amino acids serve as excitatory and inhibitory neurotransmitters, which are quickly removed to terminate nerve impulses. Amino acid transporters can be targeted to enhance inhibition or excitation, a strategy used to treat chronic pain and possibly schizophrenia and general brain damage.
Amino acids are generated from the breakdown of protein nutrition and are required as nutrients for cell growth, neurotransmission in the brain and cellular metabolism. Blocking some of these functions can treat diseases such as cancer, diabetes and chronic pain.
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